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DP family contains at least two members, DP1 and 2. Structurally, DP1 and 2 are relatively conserved, yet their expression appears to be tissue specific. E2F 1, a functional target for the tumor suppressor protein Rb, heterodimerizes with DP1 and forms an active E2F transcriptional complex. The interaction between members of the E2F and the DP families is mediated, in part, by a leucine repeat which is weakly conserved between the two families.
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Protein Aliases: AS1; ASRT1; cell cycle regulatory transcription factor DP1; down-regulated in liver cancer stem cells; DRTF1; DRTF1-polypeptide 1; E2F dimerization partner 1; E2F-related transcription factor; MGC49004; OTTHUMP00000018767; Transcription factor Dp-1
Gene Aliases: DILC; Dp-1; DP1; DRTF1; TFDP1
Molecular Function: DNA-binding transcription factor