|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 251 and 314 of Human DUSP2/PAC1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28775 targets DUSP2/PAC1 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28775 immunogen is synthetic peptide corresponding to a region within amino acids 251 and 314 of Human DUSP2/PAC1.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC-1; dual-specificity phosphatase 2; PAC1; serine/threonine specific protein phosphatase
Gene Aliases: DUSP2; PAC-1; PAC1
UniProt ID: (Human) Q05923
Entrez Gene ID: (Human) 1844
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