PA5-31644 targets DYNC1LI1 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-31644 immunogen is recombinant fragment corresponding to a region within amino acids 318 and 523 of Human DYNC1LI1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.
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Protein Aliases: cytoplasmic; Cytoplasmic dynein 1 light intermediate chain 1; cytosolic; DLC-A; DNCLI1; dynein; Dynein light chain A; dynein light chain-A; dynein light intermediate chain 1; Dynein light intermediate chain 1, cytosolic; dynein, cytoplasmic, light intermediate chain 1; dynein, cytoplasmic, light intermediate polypeptide 1; LIC1; light intermediate polypeptide 1
Gene Aliases: 1110053F02Rik; DLC-A; DNCLI1; Dnclic1; DYNC1LI1; LIC-1; LIC1