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Invitrogen
DYNLL1 Recombinant Rabbit Monoclonal Antibody (B3F3)
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FIGURE: 1 / 11
DYNLL1 Antibody (MA572153) in IHC (P)
Immunohistochemistry analysis of DYNLL1 on paraffin-embedded Mouse Cerebrum tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with DYNLL1 Recombinant Monoclonal (Product # MA572153) using a dilution at 1:200 overnight at 4°C. Followed by DAB staining.
Product Details
MA572153
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
B3F3
Immunogen
A synthesized peptide derived from human DYNLL1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1, 200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8 kDa dynein light chain; 8kD LC; 8kDa LC; cytoplasmic dynein light polypeptide; DLC1DNCLC1; DLC8; DLC8MGC126137; DNCL1; DNCL1MGC126138; dynein LC8; Dynein light chain 1, cytoplasmic; Dynein light chain LC8-type 1; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; dynein, cytoplasmic, light polypeptide 1; H LC8; LC8-type 1; MGC126137; MGC126138; mPIN; PIN; PINLC8a; Protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase; unnamed protein product
Gene Aliases: 8kDLC; DLC1; DLC8; DNCL1; DNCLC1; DYNLL1; HDLC1; LC8; LC8a; PIN
UniProt ID: (Human) P63167, (Rat) P63170, (Mouse) P63168
Entrez Gene ID: (Human) 8655, (Rat) 58945, (Mouse) 56455
enzyme inhibitor activity
protein binding
enzyme binding
nitric-oxide synthase regulator activity
nitric-oxide synthase inhibitor activity
identical protein binding
macromolecular complex binding
dynein intermediate chain binding
deoxyribonuclease inhibitor activity
scaffold protein binding
motor activity
protein C-terminus binding
protein domain specific binding
protein homodimerization activity
microtubule or microtubule-binding cytoskeletal protein
apoptotic process
cellular response to DNA damage stimulus
microtubule-based process
spermatid development
substantia nigra development
positive regulation of intracellular transport
intraciliary retrograde transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of phosphorylation
motile cilium assembly
negative regulation of nitric oxide biosynthetic process
DNA strand resection involved in replication fork processing
negative regulation of DNA strand resection involved in replication fork processing
transcription, DNA-templated
regulation of transcription, DNA-templated
nitric oxide biosynthetic process
transport
neurotransmitter metabolic process
negative regulation of catalytic activity
regulation of catalytic activity
microtubule-based movement
cilium morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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