Immunogen sequence: KQCLEWDPAV RMTPGQALRH PWLRRRLPKP PTGEKTSVKR ITESTGAITS ISKLPPPSSS ASKLRTNLAQ MTDANGNIQQ RTVLP
DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
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Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Gene Aliases: DYRK2
UniProt ID: (Human) Q92630
Entrez Gene ID: (Human) 8445