Immunofluorescent analysis of DYX1C1 showing staining in the nucleus of H1299 cells. H1299 cells were fixed in 4% paraformaldehyde at RT for 15 min and stained using a DYX1C1 polyclonal antibody (Product # PA5-31138) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10µm.
|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 183 and 406 of Human DYX1C1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-31138 targets DYX1C1 in WB applications and shows reactivity with Human samples.
The PA5-31138 immunogen is recombinant protein fragment corresponding to a region within amino acids 183 and 406 of Human DYX1C1.
This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternate splicing results in multiple transcript variants.
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