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|Tested species reactivity||Mouse|
|Host / Isotype||Sheep / IgG|
|Immunogen||residues 1-179 of mouse disabled coupled to a GST fusion protein.|
|Purification||Ammonium sulfate precipitation|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for this product is 293 cells transfected with Dab-1 HA tag.
Disruption of Dab1 results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. DAB1 acts downstream of reelin in a signalling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AI956902; C630028C02Rik; disabled homolog 1; RP23-356E21.1; scm; scr; scrambler; yot; yotari
AI956902; C630028C02Rik; Dab1; scm; scr; scrambler; yot