Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
MA5-24073
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2A
Class
Monoclonal
Type
Antibody
Clone
340531
Immunogen
E. coli-derived recombinant mouse COCO Arg24-Leu185
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607125
Product Specific Information
In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) COCO, rhDAN, recombinant mouse (rm) Gremlin, rmCerberus, and recombinant chicken Caronte is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CER2CRL2; Cerberus like-2; Cerberus-like protein 2; Cerl-2; CKTSF1B3MGC126849; DAN domain family member 5; dante; FLJ38607; GREM3cerberus 2; MGC126849
Gene Aliases: Cerl-2; Cerl2; Cerr2; coco; Dand5; Dte; Sp1
UniProt ID: (Mouse) Q76LW6
Entrez Gene ID: (Mouse) 23863
determination of left/right asymmetry in lateral mesoderm
ventricular septum development
atrial septum development
determination of left/right symmetry
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
sequestering of nodal from receptor via nodal binding
determination of heart left/right asymmetry
negative regulation of nodal signaling pathway
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support