|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (34 YQVYKSRRGIKRSEDSKE 51) of Dec1 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Dec1, which is also known as Stra13 or Sharp2, is a basic helix-loop-helix (bHLH) transcription factor that has been found to play an important role in circadian system. Dec1 contains one basic helix-loop-helix (bHLH) domain, one Orange domain and is reported to be expressed in Treg cells. It is also reported that Dec1 is required for long-term maintenance of Treg cells after adoptive transfer to suppress effector T cell-mediated inflammation. Dec1 positively regulates CD25 expression in association with Runx 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.