|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues C(155) S S S V S N P R N W L F L(168) of mouse DcTrailR1.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Suggested positive control: mouse spleen lysate or protein.
Mouse DcTRAILR1 and DcTRAILR2 (decoy TRAIL receptors 1 and 2) proteins are receptors for TRAIL according to ligand-receptor binding assays (Schneider et al. 2001). However, overexpression does not cause NF-kB activation or apoptosis, as would be expected of a TRAIL receptor. These observations led researchers to refer to these receptors as decoys. It is thought that cells that express decoy TRAIL receptor decoys at high levels relative to actual TRAIL receptors may use decoys as protection against the cytotoxic action of TRAIL (reviewed in Bouralexis et al. 2005). Additional analysis of these two murine TRAIL decoy receptors should help faciliate the understanding of the complex biology underlying TRAIL ligand/receptor interactions. DcTRAILR1 is an amino acid protein of 176 amino acids (GenBank no: NP-077252.2). DcTRAILR2 is an amino acid protein of 198 amino acids (GenBank no: AAN87807.1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dctrailr1; Decoy TRAIL receptor 1; mDcTrailr1; MGC123882; MGC123883; mSOB; TNF receptor family member SOB; TNF receptor homolog 1; Tnfrh1; Tnfrsf1al1; Tumor necrosis factor receptor p60 homolog 1; Tumor necrosis factor receptor superfamily member 23
Gene Aliases: Dctrailr1; mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1; Tnfrsf23; TNFRSFH23
UniProt ID: (Mouse) Q9ER63
Entrez Gene ID: (Mouse) 79201
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