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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (DESLAPKHPGSRKN) corresponding to the internal amino acids of DEFA1/3|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||4-6µg/ml|
|Western Blot (WB)||1-3µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DEF1; DEF3; DEFA1; DEFA2; DEFA3; defensin; defensin 3; defensin 3, neutrophil-specific; defensin alpha 1; defensin alpha 3; defensin, alpha 1, myeloid-related sequence; defensin, alpha 2; defensin, alpha 3, neutrophil-specific; HNP3; HP-1; HP-3; MRS; myeloid-related sequence; neutrophil peptide 3
DEF1; DEF3; DEFA1; DEFA2; DEFA3; HNP-1; HNP-3; HNP3; HP-1; HP-3; HP1; HP3; MRS