PA1-24902 detects Dehydroepiandrosterone from human samples.
PA1-24902 has been successfully used in radioimmune assay procedures.
The PA1-24902 immunogen is DHEA-15 alpha-CH 2 -CO, conjugated to BSA.
Reconstitute with 11 mL of 0.1M PBS, pH 7.4, with 0.1M gelatin and 15mM sodium azide.
Dehydroepiandrosterone (DHEA) is a natural steroid hormone produced from cholesterol by the adrenal glands. DHEA is also produced in the gonads, adipose tissue and the brain. DHEA is structurally similar to, and is a precursor of, androstenedione, testosterone, estradiol, estrone and estrogen. It is the most abundant hormone in the human body. Most of DHEA is sulfated (dehydroepiandrosterone sulfate- DEHAS) before secretion. DHEAS is the sulfated version of DHEA; - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS. [National Center for Biotechnology Information. PubChem Compound Database; CID=5881]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Androstenolone; C19H28O2; Dehydroisoandrosterone; DHEA; PRASTERONE