MA5-13259 targets Desmin in IF and IHC (P) applications and shows reactivity with Bovine, Canine, Chicken, Feline, Hamster, Human, Non-human primate, and Rat samples.
The MA5-13259 immunogen is desmin from human muscle.
Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. In skeletal and cardiac muscles, the staining is confined to the Z-bands giving a characteristic striated appearance. Anti-desmin antibody is useful in identification of tumors of myogenic origin. It reacts with leiomyosarcomas (smooth muscle) as well as rhabdomyosarcomas (striated muscle).
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Protein Aliases: Desmin; desmin-like protein; intermediate filament protein; mutant desmin p.K241E
Gene Aliases: BOS_2078; CSM1; CSM2; DES; I79_018932; LGMD2R