This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: KTVIICKPTM SSAEIVAVDP DEPIHGPPFD FSLESSTSEV QRMWRLKAIN DTAARLSYQN DPPFGSYVVP ITVRDRLGMS SVTSLDVTLC DCITENDCTH RVDPRIGGGG VQLGKW
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARVC10; ARVD10; Cadherin family member 2; CDHF5; CDHF6; CMD1BB; Desmocollin-2; Desmocollin-3; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III
Gene Aliases: ARVD11; CDHF2; DG2; DGII/III; DSC2; DSC3
UniProt ID: (Human) Q02487
Entrez Gene ID: (Human) 1824
Molecular Function: cadherin