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Product Details
61059
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Frozen) (IHC (F)) |
1:10 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
10G11 |
Immunogen |
Recombinant Peptide (220Aa Of 2Nd And 3Rd Extracellular Repeat Domain) |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 0.5% BSA |
Contains |
0.09% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
Specificity: desmoglein 2 present in low concentrations in all epithelia and in tumors derived therefrom as well as in heart muscle and dendritic reticulum cells of lymphatic follicles. In basal epithelial cells desmoglein 2 expression is generally very low. Polypeptide reacting: desmoglein 2 (1069aa; calculated mol. wt. 116,760)Reactivity on cultured cell lines: Many, including CaCo-2, HaCaT, MCF-7.
Target Information
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARVC10; ARVD10; Cadherin family member 5; CMD1BB; Desmoglein-2; DSG-2; HDGC; MGC117034; MGC117036; MGC117037
Gene Aliases: CDHF5; DSG2; HDGC
UniProt ID: (Human) Q14126
Entrez Gene ID: (Human) 1829
Molecular Function:
cadherin
desmosome organization
Purkinje myocyte development
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
response to progesterone
maternal process involved in female pregnancy
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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