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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant fragment (Human Desmoglein 3 extracellular domain).|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||20-50 µg/ml|
|Immunoprecipitation (IP)||5-10 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-91588 detects Desmoglein 3 from human samples. It does not cross react with Desmoglein 1 or 2.
MA1-91588 has been successfully used in immunofluorescence, immunohistochemistry (paraffin tissue), immunoprecipitation, and Western blot applications. A431 cells can be used as a positive control for this antibody.
The MA1-91588 immunogen is: Recombinant fragment (Human Desmoglein 3 extracellular domain).
Store at 4°C short term.For extended storage add 50% glycerol, aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
130 kDa pemphigus vulgaris antigen; cadherin family member 6; CDHF6; DKFZp686P23184; PVA
CDHF6; DSG3; PVA