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Proteintech
Di-Methyl-Histone H4 (Arg3) Recombinant Rabbit Monoclonal Antibody (1E21)
Product Details
82859-1-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
1E21
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
H4R3me2a/s refers to the dimethylation of arginine residue at position 3 on histone H4, specifically generating two forms: asymmetrical dimethylarginine (H4R3me2a) and symmetrical dimethylarginine (H4R3me2s). These modifications are crucial in the regulation of gene expression through epigenetic mechanisms, affecting chromatin structure and function. Recent studies suggest that H4R3me2a is linked to transcriptional activation, whereas H4R3me2s is often associated with transcriptional repression. These modifications are brought about by the activity of specific histone methyltransferases, such as PRMT1 for asymmetrical and PRMT5 for symmetrical dimethylation. The balance and dynamics of these modifications are essential for various cellular processes and can influence developmental pathways and disease pathogenesis, including cancer and metabolic disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H4 histone family, member A; H4 histone family, member B; H4 histone family, member C; H4 histone family, member D; H4 histone family, member E; H4 histone family, member G; H4 histone family, member H; H4 histone family, member I; H4 histone family, member J; H4 histone family, member K; H4 histone family, member M; H4 histone family, member N; H4 histone, family 2; histone 1, H4a; histone 1, H4b; histone 1, H4c; histone 1, H4d; histone 1, H4e; histone 1, H4f; histone 1, H4h; histone 1, H4i; histone 1, H4j; histone 1, H4k; histone 1, H4l; histone 2, H4; histone 2, H4a; histone 2, H4b; Histone 4 family, member M; histone family member; Histone H4; histone IV, family 2
Gene Aliases: dJ160A22.1; dJ160A22.2; dJ221C16.1; dJ221C16.9; FO108; H4; H4-12; H4-16; H4-53; H4.k; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4f16; H4F2; H4F2iii; H4F2iv; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; H4M; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; Hist1h4m; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4; X04652
UniProt ID: (Human) P62805, (Mouse) P62806, (Mouse) A4QMY0
chromatin silencing at rDNA
double-strand break repair via nonhomologous end joining
nucleosome assembly
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
DNA-templated transcription, initiation
telomere capping
gene silencing by RNA
telomere organization
CENP-A containing nucleosome assembly
cellular protein metabolic process
negative regulation of megakaryocyte differentiation
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
protein heterotetramerization
beta-catenin-TCF complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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