|Tested species reactivity||Bacteria|
|Host / Isotype||Mouse / IgG1|
|Immunogen||C. diphtheria lysate.|
|Storage buffer||PBS, pH 7.2|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||1:20 - 1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-7027 detects the Diphtheria toxin. This antibody is specific for the intact toxin/toxoid, and is non-reactive with free A or B subunits.
MA1-7027 has been successfully used in ELISA procedures.
The MA1-7027 immunogen is C. diphtheria lysate.
Corynebacterium diphtheriae infects the nasopharynx or skin, multiplying and secreting diphtheria toxin in nasopharyngeal or skin lesions. The diphtheria toxin is exceptionally potent with as little as 100-150 ng/kg of body weight being a lethal dose in susceptible individuals. Diphtheria toxin expression is under the control of an iron-activated repressor, DtxR. The dissociation of iron and DtxR under low iron conditions activates the tox gene, leading to its synthesis and secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.