|Tested species reactivity||Human, Non-human primate, Rat|
|Published species reactivity||Rat, Not Applicable|
|Host / Isotype||Mouse / IgG3|
|Immunogen||Fusion protein incorporating amino acid residues 252-284 of the putative third cytoplasmic loop of the human D3 receptor.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.1-1.0 ug/ml|
|Immunohistochemistry (IHC)||1-5 ug/ml|
|Immunoprecipitation (IP)||2-5 ug|
|Western Blot (WB)||1-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Distinctive expression and cellular distribution of dopamine receptors in the pancreatic islets of rats.
32-0900 was used in immunohistochemistry to localize dopamine receptors in the pancreatic islets of rats
|Chen Y,Hong F,Chen H,Fan RF,Zhang XL,Zhang Y,Zhu JX||Cell and tissue research (357:597)||2014|
D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells.
32-0900 was used in immunocytochemistry and western blot to examine the interaction of D3 and D1 receptors in rat renal proximal tubule cells
|Zeng C,Wang Z,Li H,Yu P,Zheng S,Wu L,Asico LD,Hopfer U,Eisner GM,Felder RA,Jose PA||Hypertension (Dallas, Tex. : 1979) (47:573)||2006|
||Expression of dopamine D3 receptor dimers and tetramers in brain and in transfected cells.||Nimchinsky EA,Hof PR,Janssen WG,Morrison JH,Schmauss C||The Journal of biological chemistry (272:29229)||1997|
|Rat||Not Cited||Expression of dopamine D3 receptor dimers and tetramers in brain and in transfected cells.||Nimchinsky EA,Hof PR,Janssen WG,Morrison JH,Schmauss C||The Journal of biological chemistry (272:29229)||1997|