PA5-34725 targets DBN1/Drebrin in WB applications and shows reactivity with Human samples.
The PA5-34725 immunogen is recombinant protein fragment contains a sequence corresponding to a region within amino acids 31 and 262 of Drebrin.
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The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.
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Protein Aliases: D0S117E; Developmentally-regulated brain protein; Drebrin; drebrin E; drebrin E2; drebrin-1
Gene Aliases: D0S117E; DBN1
UniProt ID: (Human) Q16643
Entrez Gene ID: (Human) 1627