Immunogen sequence: PSPILDSEET RAAAPQAWAG PMEEPPQAQA PPRGPGSPAE DLMFMESAEQ AVLAAPVEPA TADATEIHDA ADTIETDTAT ADTTVANNVP PAATSLIDLW P
The cortical cytoskeleton, a highly cross-linked submembranal F-actin filament network, plays an important role in cell proliferation, differentiation, migration, cell morphology and oncogenic transformation. Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa).
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Protein Aliases: D0S117E; Developmentally-regulated brain protein; Drebrin; drebrin E; drebrin E2; drebrin-1
Gene Aliases: D0S117E; DBN1
UniProt ID: (Human) Q16643
Entrez Gene ID: (Human) 1627