The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton.
Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension.
The protein encoded by the Drebrin gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.
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Protein Aliases: Developmentally-regulated brain protein; Drebrin; drebrin E; drebrin E2; drebrin-1
Gene Aliases: D0S117E; DBN1
UniProt ID: (Human) Q16643
Entrez Gene ID: (Human) 1627