MA1-20377 detects drebrin in human, mouse, rat, feline, porcine, chicken and guinea pig samples.
MA1-20377 has been successfully used in immunohistochemistry (frozen and paraffin) and Western blot procedures. A suggested positive control for this product is mouse brain tissue extract.
The MA1-20377 immunogen is chicken drebrin E protein.
Store at 4°C short term. For extended periods, store at -20°C, avoiding freeze/thaw cycles.
The cortical cytoskeleton, a highly cross-linked submembranal F-actin filament network, plays an important role in cell proliferation, differentiation, migration, cell morphology and oncogenic transformation. Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: D0S117E; developmentally regulated brain protein; Developmentally-regulated brain protein; DKFZp434D064; Drebrin; drebrin A; drebrin E; drebrin E2; drebrin-1
Gene Aliases: D0S117E; DBN1; Drba; drebrin