MA5-17065 targets DCTN4 in FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17065 immunogen is purified recombinant fragment of human DCTN4 (amino acids: 57-298) expressed in E. Coli.
MA5-17065 detects DCTN4 which has a predicted molecular weight of approximately 52.3kDa.
Dynactin 4 could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.The dynactin complex binds cargo, such as vesicles and organelles, to cytoplasmic dynein for retrograde microtubule-mediated trafficking and could feasibly be involved in the copper-regulated trafficking of ATP7B.
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Protein Aliases: Dyn4; dynactin 4 (p62); dynactin p62 subunit; Dynactin subunit 4; Dynactin subunit p62
Gene Aliases: DCTN4; DYN4; P62
UniProt ID: (Human) Q9UJW0
Entrez Gene ID: (Human) 51164