Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX22248-PEP)..
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.
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Protein Aliases: Dysadherin; FXYD domain-containing ion transport regulator 5; IWU-1; keratinocytes associated transmembrane protein 1
Gene Aliases: DYSAD; FXYD5; HSPC113; IWU1; KCT1; OIT2; PRO6241; RIC; UNQ2561/PRO6241
UniProt ID: (Human) Q96DB9
Entrez Gene ID: (Human) 53827