PA5-16734 targets Dystrophin in IHC (P) applications and shows reactivity with Human and Rat samples.
The PA5-16734 immunogen is a synthetic peptide corresponding to C-terminal of human Dystrophin.
Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immuohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.
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Protein Aliases: apodystrophin-3; apodystrophin-I; Dystrophin; dystrophin, muscular dystrophy; OTTHUMP00000215592
Gene Aliases: BMD; CMD3B; DMD; DNADMD1; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; MRX85