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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||TBS with 1% BSA|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Inhibition Assays (IA)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment.
13-5700 was used in immunocytochemistry to study the mechanism for the metastasis of ErbB2-positive breast cancer cells.
|Rayavarapu RR,Heiden B,Pagani N,Shaw MM,Shuff S,Zhang S,Schafer ZT||The Journal of biological chemistry (290:8722)||2015|
α-Catenin contributes to the strength of E-cadherin-p120 interactions.
13-5700 was used in immunocytochemistry and immunoprecipitation to study the effect of α-catenin-p120 interactions.
|Troyanovsky RB,Klingelhöfer J,Troyanovsky SM||Molecular biology of the cell (22:4247)||2011|
Inhibition of cadherin function differentially affects markers of terminal differentiation in cultured human keratinocytes.
13-5700 was used in blocking assay to test if cadherin-cadherin interactions modulate keratinocyte differentiation.
|Hines MD,Jin HC,Wheelock MJ,Jensen PJ||Journal of cell science (112 ( Pt 24):4569)||1999|
Arc-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin-1; cadherin-E; calcium-dependent adhesion protein; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDHE; cell-CAM 120/80; E-Cadherin; E-cadherin 1; E-cadherin epithelial; ECAD; epithelial; epithelial cadherin; LCAM; UVO; uvomorulin
Arc-1; CD324; CDH1; CDHE; ECAD; LCAM; UVO