|Tested species reactivity||Human, Rat|
|Host / Isotype||Mouse / IgG|
|Immunogen||Synthetic peptide to C-terminal region of EDG3 (Human).|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-91361 detects EDG3 from human, rat samples.
MA1-91361 has been successfully used in Western blot applications.
The MA1-91361 immunogen is: Synthetic peptide to C-terminal region of EDG3 (Human).
EDG3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several protein tyrosine kinases. EDG3 is expressed in heart, placenta, kidney, and liver tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.