FIGURE: 1 / 3
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
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Protein Aliases: Endothelin-3; ET 3; ET-3; MGC15067; MGC61498; PPET3; Preproendothelin 3; Preproendothelin-3; RP4-614C15.1
Gene Aliases: EDN3; ET-3; ET3; HSCR4; PPET3; WS4B
UniProt ID: (Human) P14138
Entrez Gene ID: (Human) 1908
Molecular Function: peptide hormone