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Abnova
EDNRB Monoclonal Antibody (5H2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
H00001910-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
5H2
Immunogen
EDNRB (AAH14472.1, 27 a.a. approximately 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: EERGFPPDRA TPLLQTAEIM TPPTKTLWPK GSNASLARSL APAEVPKGDR TAGSPPRTIS PPPCQGPIEI KETFK
Target Information
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AU022549; endothelin receptor non-selective type; endothelin receptor subtype B1; Et-b receptor; Et-b-r; ET-RB; Etb receptor; Etb-svr; G-protein coupled receptor; Hirschsprung disease 2; RP11-318G21.1; unnamed protein product
Gene Aliases: ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB; HSCR; HSCR2; WS4A
UniProt ID: (Human) P24530
Entrez Gene ID: (Human) 1910
negative regulation of transcription from RNA polymerase II promoter
renin secretion into blood stream
regulation of heart rate
cGMP biosynthetic process
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
nervous system development
regulation of blood pressure
positive regulation of cell proliferation
gene expression
negative regulation of neuron maturation
vein smooth muscle contraction
vascular smooth muscle contraction
calcium-mediated signaling
melanocyte differentiation
regulation of fever generation
aldosterone metabolic process
response to lipopolysaccharide
enteric smooth muscle cell differentiation
positive regulation of urine volume
renal sodium excretion
epithelial fluid transport
vasoconstriction
vasodilation
negative regulation of apoptotic process
pigmentation
developmental pigmentation
macrophage chemotaxis
response to pain
enteric nervous system development
regulation of epithelial cell proliferation
negative regulation of protein metabolic process
sodium ion homeostasis
canonical Wnt signaling pathway
positive regulation of penile erection
renal sodium ion absorption
calcium ion transmembrane transport
cellular response to lipopolysaccharide
endothelin receptor signaling pathway
chordate pharynx development
response to sodium phosphate
response to endothelin
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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