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|Tested species reactivity||Human|
|Published species reactivity||Yeast, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified extracellular and cytoplasmic domains of human recombinant EGFR protein.|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Epidermal Growth Factor Receptor (EGFR) is a 175 kDa transmembrane glycoprotein belonging to tyrosine kinase superfamily. It acts as a receptor for epidermal growth factor (EGF) family proteins. Binding of EGFR to its ligands causes autophosphorylation of tyrosine kinase followed by activation of signal transduction pathways connected to cell proliferation and differentiation. Tyrosine 1068 present within the cytoplasmic domain of the receptor is a major autophosphorylation site that allows binding of Grb2 and activation of the Ras-Raf-ERK1 and ERK2 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
An evolved Mxe GyrA intein for enhanced production of fusion proteins.
AHR5062 was used in flow cytometry to optimize an intein generating system in yeast instead of bacteria
|Marshall CJ,Grosskopf VA,Moehling TJ,Tillotson BJ,Wiepz GJ,Abbott NL,Raines RT,Shusta EV||ACS chemical biology (10:527)||2015|
EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling.
AHR5062 was used in immunoprecipitation and western blot to examine the effects of kinase inhibtors that target the epidermal growth factor receptor in lung cancer
|Arasada RR,Amann JM,Rahman MA,Huppert SS,Carbone DP||Cancer research (74:5572)||2014|
|Human||Not Cited||Sialyl Lewis X modification of the epidermal growth factor receptor regulates receptor function during airway epithelial wound repair.||Allahverdian S,Wang A,Singhera GK,Wong BW,Dorscheid DR||Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (40:607)||2010|
|Human||Not Cited||Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior.||Majumdar S,Gong EM,Di Vizio D,Dreyfuss J,Degraff DJ,Hager MH,Park PJ,Bellmunt J,Matusik RJ,Rosenberg JE,Adam RM||Neoplasia (New York, N.Y.) (15:749)||2013|
||Sialyl Lewis X modification of the epidermal growth factor receptor regulates receptor function during airway epithelial wound repair.||Allahverdian S,Wang A,Singhera GK,Wong BW,Dorscheid DR||Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (40:607)||2010|
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 184.108.40.206; Epidermal growth factor receptor; Epidermal growth factor receptor precursor; erb-b2 receptor tyrosine kinase 1; ERBB1; kinase EGFR; Proto-oncogene c-ErbB-1; Receptor protein-tyrosine kinase ErbB-1; Receptor tyrosine-protein kinase erbB-1
EGFR; ERBB; ERBB1; HER1; mENA; NISBD2; PIG61