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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (RLGKYYVKERSK) corresponding to the internal amino acids of EGLN3|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.1-0.3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EGL nine (C.elegans) homolog 3; egl nine homolog 3; egl nine homolog 3 (C. elegans); egl nine-like protein 3 isoform; egl-9 family hypoxia-inducible factor 3; EGLN3; FLJ21620; HIF prolyl hydroxylase 3; HIF-PH3; HIF-prolyl hydroxylase 3; HIFPH3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; MGC125998; MGC125999; PHD3; prolyl hydroxylase domain-containing protein 3
EGLN3; HIFP4H3; HIFPH3; PHD3