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Invitrogen

EGR1 Recombinant Rat Monoclonal Antibody (HEGR1DS)

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Product Details

740183T

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunocytochemistry (ICC/IF)

1:200
-

Flow Cytometry (Flow)

0.25 µg/test
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rat / IgG2a

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

HEGR1DS

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3719664

Product Specific Information

Recombinant rat monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Target Information

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AT225; Early growth response protein 1; EGR-1; ETR103; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; unnamed protein product; zinc finger gene 225; Zinc finger protein 225; Zinc finger protein Krox-24

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Gene Aliases: AT225; EGR1; G0S30; KROX-24; KROX24; NGFI-A; TIS8; ZIF-268; ZIF268; ZNF225

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UniProt ID: (Human) P18146

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Entrez Gene ID: (Human) 1958

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding double-stranded methylated DNA binding enzyme binding histone acetyltransferase binding sequence-specific DNA binding hemi-methylated DNA-binding metal ion binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia response to ischemia regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to glucose positive regulation of gene expression T cell differentiation BMP signaling pathway positive regulation of chemokine production positive regulation of interleukin-1 beta production response to insulin circadian regulation of gene expression regulation of protein sumoylation skeletal muscle cell differentiation regulation of apoptotic process regulation of neuron apoptotic process hypomethylation of CpG island estrous cycle locomotor rhythm positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone biosynthetic process rhythmic process circadian temperature homeostasis interleukin-1-mediated signaling pathway cellular response to gamma radiation cellular response to heparin cellular response to mycophenolic acid glomerular mesangial cell proliferation positive regulation of glomerular metanephric mesangial cell proliferation negative regulation of canonical Wnt signaling pathway cellular response to interleukin-8 positive regulation of post-translational protein modification positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of progesterone biosynthetic process
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