Invitrogen

EGR2 Recombinant Rat Monoclonal Antibody (erongr2)

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Datasheet
Protocols
Questions & Answers

Product Details

740043T

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Flow Cytometry (Flow)

0.06-2 µg/test
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2a, kappa

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

erongr2

Immunogen

E. coli-derived protein, aa 1-319

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3679148

Product Specific Information

Recombinant rat monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Target Information

The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; Early growth response protein 2; EGR-2; FLJ1454; FLJ14547; Krox-20 homolog; OTTHUMP00000062133; Zinc finger protein Krox-20

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Gene Aliases: Egr-2; Egr2; Krox-20; Krox20; NGF1-B; Zfp-25; Zfp-6

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UniProt ID: (Mouse) P08152

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Entrez Gene ID: (Mouse) 13654

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity ribosomal S6-glutamic acid ligase activity ubiquitin protein ligase binding coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity transcription regulatory region DNA binding metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity HMG box domain binding C2H2 zinc finger transcription factor
Process(es)
transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter protein export from nucleus rhythmic behavior motor neuron axon guidance Schwann cell differentiation rhombomere 3 development facial nerve structural organization rhombomere 3 formation rhombomere 5 formation regulation of ossification response to insulin brain segmentation skeletal muscle cell differentiation myelination negative regulation of apoptotic process fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neuronal synaptic plasticity cellular response to organic substance cellular response to cAMP cellular response to gonadotropin stimulus
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