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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human EIF2AK3 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15705 targets EIF2AK3 in WB applications and shows reactivity with Human samples.
The MA5-15705 immunogen is purified recombinant fragment of human EIF2AK3 expressed in E. Coli.
MA5-15705 detects EIF2AK3 which has a predicted molecular weight of approximately 125kDa.
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 , leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum , where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EIF2AK3; Eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; Pancreatic eIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase; WRS
EIF2AK3; PEK; PERK; WRS