|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 66 and 325 of Human EIF3 beta|
|Storage buffer||PBS, pH 7, with 40% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27582 targets EIF3 beta in IF and WB applications and shows reactivity with Human samples.
The PA5-27582 immunogen is recombinant fragment corresponding to a region within amino acids 66 and 325 of Human EIF3 beta.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: eIF-3-beta; eIF3 p36; eIF3-beta; eIF3-p36; eIF3i; EIF3S2; eukaryotic translation initiation factor 3; Eukaryotic translation initiation factor 3 subunit 2; Eukaryotic translation initiation factor 3 subunit I; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa; eukaryotic translation initiation factor 3, subunit I; predicted protein of HQ2242; PRO2242; subuni; TGF-beta receptor-interacting protein 1; TGFbeta receptor-interacting protein 1; TRIP-1
Gene Aliases: eIF3-beta; eIF3-p36; EIF3I; EIF3S2; PRO2242; TRIP-1; TRIP1
UniProt ID: (Human) Q13347
Entrez Gene ID: (Human) 8668
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