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Proteintech
EIF4E Monoclonal Antibody (3C6B9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
66655-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3C6B9
Immunogen
EIF4E Fusion Protein Ag27191 (1-217 aa encoded by BC012611)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATVEPETT PTPNPPTTEE EKTESNQEVA NPEHYIKHPL QNRWALWFFK NDKSKTWQAN LRLISKFDTV EDFWALYNHI QLSSNLMPGC DYSLFKDGIE PMWEDEKNKR GGRWLITLNK QQRRSDLNRF WLETLLCLIG ESFDDYSDDV CGAVVNVRAK GDKIAIWTTE CENREAVTHI GRVYKERLGL PPKIVIGYQS HADTATKSGS TTKNRFVV (1-217 aa encoded by BC012611)
Target Information
eIF4E is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A, that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: eIF-4E; eIF-4F 25 kDa subunit; eukaryotic initiation factor 4E; eukaryotic translation initiation factor 4E-like 1; MGC111573; mRNA cap-binding protein; OTTHUMP00000219703; OTTHUMP00000219704; OTTHUMP00000219705; unnamed protein product
Gene Aliases: AUTS19; CBP; EG668879; eIF-4E; Eif4e-ps; EIF4E1; EIF4EL1; EIF4F; If4e
UniProt ID: (Human) P06730, (Rat) P63074, (Mouse) P63073
Entrez Gene ID: (Human) 1977, (Rat) 117045, (Mouse) 13684
G1/S transition of mitotic cell cycle
mRNA export from nucleus
translational initiation
regulation of translation
negative regulation of autophagy
negative regulation of translation
positive regulation of mitotic cell cycle
nuclear export
regulation of translation at postsynapse, modulating synaptic transmission
behavioral fear response
stem cell population maintenance
lung development
negative regulation of neuron differentiation
cellular response to dexamethasone stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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