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Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1-5 µg/mL | - |
Immunocytochemistry (ICC/IF) |
10 µg/mL | - |
ELISA (ELISA) |
10 µg/mL | - |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2b, kappa |
Class |
Monoclonal |
Type |
Antibody |
Clone |
1E5 |
Immunogen |
ENG (AAH14271, 27 a.a. approximately 658 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
See Label |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Sequence of this protein is as follows: TVHCDLQPVG PERDEVTYTT SQVSKGCVAQ APNAILEVHV LFLEFPTGPS QLELTLQASK QNGTWPREVL LVLSVNSSVF LHLQALGIPL HLAYNSSLVT FQEPPGVNTT ELPSFPKTQI LEWAAERGPI TSAAELNDPQ SILLRLGQAQ GSLSFCMLEA SQDMGRTLEW RPRTPALVRG CHLEGVAGHK EAHILRVLPG HSAGPRTVTV KVELSCAPGD LDAVLILQGP PYVSWLIDAN HNMQIWTTGE YSFKIFPEKN IRGFKLPDTP QGLLGEARML NASIVASFVE LPLASIVSLH ASSCGGRLQT SPAPIQTTPP KDTCSPELLM SLIQTKCADD AMTLVLKKEL VAHLKCTITG LTFWDPSCEA EDRGDKFVLR SAYSSCGMQV SASMISNEAV VNILSSSSPQ RKKVHCLNMD SLSFQLGLYL SPHFLQASNT IEPGQQSFVQ VRVSPSVSEF LLQLDSCHLD LGPEGGTVEL IQGRAAKGNC VSLLSPSPEG DPRFSFLLHF YTVPIPKTGT LSCTVALRPK TGSQDQEVHR TVFMRLNIIS PDLSGCTSKG LVLPAVLGIT FGAFLIGALL TAALWYIYSH TRSPSKREPV VAVAAPASSE SSSTNHSIGS TQSTPCSTSS MA
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD105; CD105 antigen; Endoglin; ORW
Gene Aliases: END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022
Molecular Function:
transmembrane signal receptor
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