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Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:200-1:4000 | - |
Immunocytochemistry (ICC/IF) |
1:100 | - |
Product Specifications | |
---|---|
Species Reactivity |
Dog, Human, Mouse, Rat |
Host/Isotype |
Mouse / IgG2b |
Class |
Monoclonal |
Type |
Antibody |
Clone |
OTI8A1 |
Immunogen |
Full length human recombinant protein of human ENG produced in HEK293T cell. |
Conjugate |
Unconjugated
|
Form |
liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 1% BSA, 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD105; CD105 antigen; Cell surface MJ7/18 antigen; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); ORW; transmembrane glycoprotein
Gene Aliases: AI528660; AI662476; CD105; Edg; END; Endo; ENG; HHT1; ORW1; S-endoglin
UniProt ID: (Human) P17813, (Mouse) Q63961
Entrez Gene ID: (Human) 2022, (Dog) 609166, (Mouse) 13805, (Rat) 497010
Molecular Function:
transmembrane signal receptor
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