CPEB4-Dependent Neonate-Born Granule Cells Are Required for Olfactory Discrimination.
Frontiers in behavioral neuroscience
Tseng CS,Chou SJ,Huang YS
12-4875-82 was used in Immunohistochemistry to suggest that granule cells (GCs) born in the early postnatal olfactory bulb (OB) are required for olfactory discrimination.
Wed Sep 30 00:00:00 EDT 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
12-4875 was used in Flow cytometry/Cell sorting to show that the AHR pathway is selectively active in IDO/TDO-overexpressing tumors and is associated with resistance to immune checkpoint inhibitors.
Tue Aug 11 00:00:00 EDT 2020
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
12-4875 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 EDT 2020
Centrosome anchoring regulates progenitor properties and cortical formation.
Shao W,Yang J,He M,Yu XY,Lee CH,Yang Z,Joyner AL,Anderson KV,Zhang J,Tsou MB,Shi H,Shi SH
12-4875-82 was used in Immunohistochemistry to indicate a previously unknown role of the centrosome in regulating the mechanical features of neural progenitor cells and the size and configuration of the mammalian cerebral cortex.
Wed Apr 01 00:00:00 EDT 2020
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.
Zhang Y,Liu G,Guo T,Liang XG,Du H,Yang L,Bhaduri A,Li X,Xu Z,Zhang Z,Li Z,He M,Tsyporin J,Kriegstein AR,Rubenstein JL,Yang Z,Chen B
12-4875 was used in Immunohistochemistry to demonstrate that GSX2+ cells are tri-potent intermediate progenitor cells (tri-IPCs), giving rise to OB-INs, cortical oligodendrocytes, and astrocytes.
Tue Mar 31 00:00:00 EDT 2020
Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.
The Journal of experimental medicine
Fachi JL,Sécca C,Rodrigues PB,Mato FCP,Di Luccia B,Felipe JS,Pral LP,Rungue M,Rocha VM,Sato FT,Sampaio U,Clerici MTPS,Rodrigues HG,Câmara NOS,Consonni SR,Vieira AT,Oliveira SC,Mackay CR,Layden BT,Bortoluci KR,Colonna M,Vinolo MAR
12-4875 was used in Flow cytometry/Cell sorting to study the impact of a microbiota-derived metabolite, short-chain fatty acid acetate, on an acute mouse model of CDI.
Mon Mar 02 00:00:00 EST 2020
Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.
Cancer immunology research
Shi LZ,Goswami S,Fu T,Guan B,Chen J,Xiong L,Zhang J,Ng Tang D,Zhang X,Vence L,Blando J,Allison JP,Collazo R,Gao J,Sharma P
12-4875 was used in Flow cytometry/Cell sorting to provides a foundation of testing combinatorial therapy of ACT of CD8 T cells and dual blocking of CTLA-4 and PD-1 in patients with melanoma.
Fri Nov 01 00:00:00 EDT 2019
Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice.
Huang TN,Yen TL,Qiu LR,Chuang HC,Lerch JP,Hsueh YP
12-4875 was used in Immunohistochemistry-immunofluorescence to investigate the role of TBR1 in regulating olfaction and test whether D-cycloserine can also improve olfactory defects in Tbr1 mutant mice.
Thu Apr 11 00:00:00 EDT 2019
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.
Myers LM,Tal MC,Torrez Dulgeroff LB,Carmody AB,Messer RJ,Gulati G,Yiu YY,Staron MM,Angel CL,Sinha R,Markovic M,Pham EA,Fram B,Ahmed A,Newman AM,Glenn JS,Davis MM,Kaech SM,Weissman IL,Hasenkrug KJ
12-4875-82 was used in Flow Cytometry to demonstrate that even during exhaustion there is a subset of functional CD8+ T cells defined by surface expression of SIRPα.
Fri Feb 15 00:00:00 EST 2019
Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity.
Van Braeckel-Budimir N,Varga SM,Badovinac VP,Harty JT
12-4875 was used in Flow cytometry/Cell sorting to demonstrate that, relative to single virus exposure, repeated antigen exposure dramatically alters the dynamics of influenza-specific lung-resident primary memory CD8+ T cell populations.
Tue Sep 25 00:00:00 EDT 2018
Dependence of innate lymphoid cell 1 development on NKp46.
Wang Y,Dong W,Zhang Y,Caligiuri MA,Yu J
12-4875 was used in Flow cytometry/Cell sorting to reveal that NKp46 selectively participates in the regulation of ILC1 development.
Sun Apr 01 00:00:00 EDT 2018
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.
Chatterjee S,Daenthanasanmak A,Chakraborty P,Wyatt MW,Dhar P,Selvam SP,Fu J,Zhang J,Nguyen H,Kang I,Toth K,Al-Homrani M,Husain M,Beeson G,Ball L,Helke K,Husain S,Garrett-Mayer E,Hardiman G,Mehrotra M,Nishimura MI,Beeson CC,Bupp MG,Wu J,Ogretmen B,Paulos CM,Rathmell J,Yu XZ,Mehrotra S
12-4875 was used in Flow cytometry/Cell sorting to establish ex vivo culture conditions to generate hybrid Th1/17 cells, which persist long-term in vivo while maintaining effector function.
Tue Jan 09 00:00:00 EST 2018
TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells.
European journal of immunology
Yoshizawa A,Bi K,Keskin DB,Zhang G,Reinhold B,Reinherz EL
12-4875 was used in Flow cytometry/Cell sorting to show TCR-pMHC interactions among TR and antigen presenting cells in a tissue milieu strongly impact CD8 T cell biology.
Mon Jan 01 00:00:00 EST 2018
Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis.
Human molecular genetics
Khacho M,Clark A,Svoboda DS,MacLaurin JG,Lagace DC,Park DS,Slack RS
12-4875 was used in Immunocytochemistry-immunoflourescence to show that mitochondrial dysfunction impairs brain development, depletes the adult neural stem cell pool and impacts embryonic and adult neurogenesis.
Fri Sep 01 00:00:00 EDT 2017
Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
Wells AC,Daniels KA,Angelou CC,Fagerberg E,Burnside AS,Markstein M,Alfandari D,Welsh RM,Pobezinskaya EL,Pobezinsky LA
12-4875 was used in Flow cytometry/Cell sorting to identify a let-7-mediated mechanism that acts as a molecular brake controlling the magnitude of CD8 T-cell responses.
Mon Jul 24 00:00:00 EDT 2017
Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto.
Martínez Gómez JM,Periasamy P,Dutertre CA,Irving AT,Ng JH,Crameri G,Baker ML,Ginhoux F,Wang LF,Alonso S
12487582 was used in flow cytometry to describe the phenotypic and functional characterization of T cell subsets, B and NK cells in the fruit-eating bat Pteropus alecto
Thu Nov 24 00:00:00 EST 2016
TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections.
The Journal of clinical investigation
Lewis GM,Wehrens EJ,Labarta-Bajo L,Streeck H,Zuniga EI
12-4875 was used in Flow cytometry/Cell sorting to uncover an eomesodermin-driven CD4 T cell program that is continuously suppressed by TGF-β signalling.
Mon Oct 03 00:00:00 EDT 2016
IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia.
Cell & bioscience
Xu A,Bhanumathy KK,Wu J,Ye Z,Freywald A,Leary SC,Li R,Xiang J
12-4875 was used in Flow cytometry/Cell sorting to investigate the mechanism for adoptively transferred effector T-cell survival and memory formation.
Mon May 09 00:00:00 EDT 2016
Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation.
Carty SA,Koretzky GA,Jordan MS
12-4875 was used in Flow cytometry/Cell sorting to investigate the signaling pathways required for IL-4 induction of Eomes and CD8(+) innate-like lymphocyte markers in murine CD8SP thymocytes and peripheral CD8(+) T cells.
Thu May 21 00:00:00 EDT 2015
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA
12-4875 was used in Flow cytometry/Cell sorting to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.
Fri Sep 21 00:00:00 EDT 2012
Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mizuguchi R,Naritsuka H,Mori K,Mao CA,Klein WH,Yoshihara Y
12-4875-82 was used in Immunohistochemistry to study the molecular mechanisms underlying the formation of functional neural circuitry among various types of neurons inside the olfactory bulb.
Wed Jun 27 00:00:00 EDT 2012
IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.
Journal of immunology (Baltimore, Md. : 1950)
Marshall HD,Prince AL,Berg LJ,Welsh RM
Sun Aug 01 00:00:00 EDT 2010