Product References
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Fri Mar 24 00:00:00 EDT 2023
PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity.
Cancer discovery
Wiede F,Lu KH,Du X,Zeissig MN,Xu R,Goh PK,Xirouchaki CE,Hogarth SJ,Greatorex S,Sek K,Daly RJ,Beavis PA,Darcy PK,Tonks NK,Tiganis T
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3.
Nature immunology
Grebinoski S,Zhang Q,Cillo AR,Manne S,Xiao H,Brunazzi EA,Tabib T,Cardello C,Lian CG,Murphy GF,Lafyatis R,Wherry EJ,Das J,Workman CJ,Vignali DAA
46-4875-82 was used in Flow cytometry/Cell sorting to show that intra-islet CD8+ T cells phenotypically, transcriptionally, epigenetically and metabolically possess features of canonically exhausted T cells, yet maintain important differences.
Wed Jun 01 00:00:00 EDT 2022
Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.
Nature communications
Darragh LB,Gadwa J,Pham TT,Van Court B,Neupert B,Olimpo NA,Nguyen K,Nguyen D,Knitz MW,Hoen M,Corbo S,Joshi M,Zhuang Y,Amann M,Wang XJ,Dow S,Kedl RM,Samedi V,Boss MK,Karam SD
46-4875-82 was used in Flow cytometry/Cell sorting to support using lymphatic sparing radiation therapy for head and neck cancer.
Wed Nov 16 00:00:00 EST 2022
CD8+ T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis.
Cell death & disease
Feizi N,Focaccetti C,Pacella I,Tucci G,Rossi A,Costanza M,Pedotti R,Sidney J,Sette A,La Rocca C,Procaccini C,Matarese G,Barnaba V,Piconese S
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Fri Oct 29 00:00:00 EDT 2021
B cells promote CD8 T cell primary and memory responses to subunit vaccines.
Cell reports
Klarquist J,Cross EW,Thompson SB,Willett B,Aldridge DL,Caffrey-Carr AK,Xu Z,Hunter CA,Getahun A,Kedl RM
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Tue Aug 24 00:00:00 EDT 2021
Interferon Lambda Regulates Cellular and Humoral Immunity in Pristane-Induced Lupus.
International journal of molecular sciences
Aschman T,Schaffer S,Biniaris Georgallis SI,Triantafyllopoulou A,Staeheli P,Voll RE
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Fri Oct 29 00:00:00 EDT 2021
Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.
JCI insight
Hope HC,Brownlie RJ,Fife CM,Steele L,Lorger M,Salmond RJ
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
Sex-specific adipose tissue imprinting of regulatory T cells.
Nature
Vasanthakumar A,Chisanga D,Blume J,Gloury R,Britt K,Henstridge DC,Zhan Y,Torres SV,Liene S,Collins N,Cao E,Sidwell T,Li C,Spallanzani RG,Liao Y,Beavis PA,Gebhardt T,Trevaskis N,Nutt SL,Zajac JD,Davey RA,Febbraio MA,Mathis D,Shi W,Kallies A
46-4875-82 was used in Flow Cytometry to find that sex-specific differences in Treg cells from visceral adipose tissue are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
Sun Mar 01 00:00:00 EST 2020
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.
The Journal of experimental medicine
Oda SK,Anderson KG,Ravikumar P,Bonson P,Garcia NM,Jenkins CM,Zhuang S,Daman AW,Chiu EY,Bates BM,Greenberg PD
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Mon Dec 07 00:00:00 EST 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Tue Sep 22 00:00:00 EDT 2020
Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance.
Cell reports
Goh W,Scheer S,Jackson JT,Hediyeh-Zadeh S,Delconte RB,Schuster IS,Andoniou CE,Rautela J,Degli-Esposti MA,Davis MJ,McCormack MP,Nutt SL,Huntington ND
46-4875 was used in Flow cytometry/Cell sorting to show homeobox transcriptional regulator Hhex regulates NK cell homeostasis and immunity.
Tue Oct 20 00:00:00 EDT 2020
Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity.
Cell reports
Wagner JA,Wong P,Schappe T,Berrien-Elliott MM,Cubitt C,Jaeger N,Lee M,Keppel CR,Marin ND,Foltz JA,Marsala L,Neal CC,Sullivan RP,Schneider SE,Keppel MP,Saucier N,Cooper MA,Fehniger TA
46-4875 was used in Flow cytometry/Cell sorting to develop a tamoxifen-inducible, type-1-ILC-specific (Ncr1-targeted) cre mouse and combine this with Eomes-floxed mice.
Tue Jun 02 00:00:00 EDT 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Thu Jul 11 00:00:00 EDT 2019
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
46-4875 was used in Flow cytometry/Cell sorting to identify a discrete ILC2-committed population and delineated transition states between early progenitors and a highly heterogeneous ILC1, ILC3, and NK precursor cell cluster.
Tue Jul 16 00:00:00 EDT 2019
EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming.
Nature communications
Istaces N,Splittgerber M,Lima Silva V,Nguyen M,Thomas S,Le A,Achouri Y,Calonne E,Defrance M,Fuks F,Goriely S,Azouz A
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Wed Jul 24 00:00:00 EDT 2019
mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.
Open life sciences
Wang H,Xiao Y,Su L,Cui N,Liu D
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.
Nature communications
Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Tue Oct 30 00:00:00 EDT 2018
IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.
International journal of medical sciences
Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Mon May 21 00:00:00 EDT 2018
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.
Nature communications
Klein JC,Moses K,Zelinskyy G,Sody S,Buer J,Lang S,Helfrich I,Dittmer U,Kirschning CJ,Brandau S
46-4875 was used in Flow cytometry/Cell sorting to demonstrate that cells deficient in endosomal TLR3, 7 and 9 leads to tumour regression and anti-tumour immunity.
Thu Mar 16 00:00:00 EDT 2017
CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.
European journal of immunology
Dong H,Franklin NA,Ritchea SB,Yagita H,Glennie MJ,Bullock TN
46-4875 was used in Flow cytometry/Cell sorting to identify complex interactions between signal 3 and costimulatory pathways, and identify opportunities to influence the differentiation of CD8(+) T-cell responses.
Tue Dec 01 00:00:00 EST 2015
FoxO3 is a negative regulator of primary CD8+ T-cell expansion but not of memory formation.
Immunology and cell biology
Togher S,Larange A,Schoenberger SP,Feau S
46-4875 was used in Flow cytometry/Cell sorting to show that FoxO3 is a negative regulator of the CD8(+) T-cell response, in particular during the primary expansion.
Sun Feb 01 00:00:00 EST 2015
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Qui HZ,Hagymasi AT,Bandyopadhyay S,St Rose MC,Ramanarasimhaiah R,Ménoret A,Mittler RS,Gordon SM,Reiner SL,Vella AT,Adler AJ
Published figure using EOMES monoclonal antibody (Product # 46-4875-82) in Flow Cytometry
Sat Oct 01 00:00:00 EDT 2011
IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.
Journal of immunology (Baltimore, Md. : 1950)
Marshall HD,Prince AL,Berg LJ,Welsh RM
Sun Aug 01 00:00:00 EDT 2010