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NeoBiotechnologies
ER-beta (Estrogen Receptor beta-2) Monoclonal Antibody (57/3)
Product Details
2100-MSM11-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
57/3
Immunogen
A synthetic peptide (CGMKMETLLPEATMEQ ) from the C terminus of the human estrogen receptor beta 2 isomer
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
This MAb recognizes the estrogen receptor beta 2 isoform, expressed in cell nuclei of a range of human tissues including ovary, placenta, testis and vas deferens. No cross-reactivity is seen with estrogen receptor beta 1 isoform. This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ER beta; ER-beta; Estrogen Receptor 2; estrogen receptor 2 (ER beta); Estrogen receptor beta; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2
Gene Aliases: ER-BETA; Erb; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2
UniProt ID: (Human) Q92731
Entrez Gene ID: (Human) 2100
core promoter sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid binding
protein binding
drug binding
zinc ion binding
enzyme binding
estrogen receptor activity
estrogen response element binding
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
peroxisome proliferator activated receptor binding
receptor antagonist activity
estradiol binding
steroid hormone binding
negative regulation of transcription from RNA polymerase II promoter
ovarian follicle development
behavioral fear response
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
signal transduction
cell-cell signaling
learning or memory
response to water deprivation
response to activity
response to insecticide
cerebellum development
amygdala development
hypothalamus development
negative regulation of cell growth
intracellular estrogen receptor signaling pathway
prostate gland development
response to nutrient levels
response to testosterone
response to genistein
cellular response to drug
positive regulation of apoptotic process
regulation of neuron apoptotic process
response to estrogen
response to human chorionic gonadotropin
estrous cycle
response to ethanol
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of smooth muscle cell proliferation
negative regulation of epithelial cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
Sertoli cell development
Sertoli cell proliferation
positive regulation of ERK1 and ERK2 cascade
cellular response to magnetism
cellular response to estradiol stimulus
response to dexamethasone
extracellular negative regulation of signal transduction
negative regulation of neuron death
response to salt
response to bisphenol A
negative regulation of feeding behavior
negative regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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