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Product Details
H00055914-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
10D2
Immunogen
ERBB2IP (NP_061165, 1272 a.a. approximately 1371 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: QGHELAKQEI RVRVEKDPEL GFSISGGVGG RGNPFRPDDD GIFVTRVQPE GPASKLLQPG DKIIQANGYS FINIEHGQAV SLLKTFQNTV ELIIVREVSS
Target Information
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Densin-180-like protein; epididymis secretory protein Li 78; Erbb2-interacting protein; Erbin; Protein LAP2
Gene Aliases: ERBB2IP; ERBIN; HEL-S-78; KIAA1225; LAP2
UniProt ID: (Human) Q96RT1
Entrez Gene ID: (Human) 55914
protein targeting
cell cycle
cell adhesion
signal transduction
epidermal growth factor receptor signaling pathway
integrin-mediated signaling pathway
cell growth
negative regulation of NF-kappaB transcription factor activity
response to muramyl dipeptide
response to lipopolysaccharide
ERBB2 signaling pathway
intermediate filament cytoskeleton organization
basal protein localization
establishment or maintenance of epithelial cell apical/basal polarity
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to tumor necrosis factor
negative regulation of monocyte chemotactic protein-1 production
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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