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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human ERI1, corresponding to a region within C-terminal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol, 150mM NaCl |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2851462 |
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3 ' exoribonuclease; 3' exoribonuclease; 3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; enhanced RNAi protein 1; enhanced RNAi three prime mRNA exonuclease homolog 1; Eri-1 homolog; HEXO; histone mRNA 3' end-specific exonuclease; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; protei; Protein 3'hExo; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1
Gene Aliases: 3'EXO; 3'HEXO; 3110010F15Rik; eri-1; ERI1; HEXO; RGD1308378; THEX1
UniProt ID: (Human) Q8IV48, (Rat) Q5FVR4, (Mouse) Q7TMF2
Entrez Gene ID: (Human) 90459, (Rat) 361159, (Mouse) 67276
Molecular Function:
exoribonuclease
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