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          • Primary Antibodies ›
          • ERI1 Antibodies

          Invitrogen

          ERI1 Polyclonal Antibody

          View all (10) ERI1 antibodies
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          Cite ERI1 Polyclonal Antibody

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          • Antibody Testing Data (2)
          ERI1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          ERI1 Antibody (PA5-102031) in ICC/IF

          Immunofluorescent analysis of ERI1 in HepG2. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with ERI1 polyclonal antibody (Product # PA5-102031) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          PA5-102031

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human ERI1, corresponding to a region within C-terminal amino acids.
          View immunogen

          Conjugate

          Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          RRID

          AB_2851462

          Target Information

          RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: 3 ' exoribonuclease; 3' exoribonuclease; 3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; enhanced RNAi protein 1; enhanced RNAi three prime mRNA exonuclease homolog 1; Eri-1 homolog; HEXO; histone mRNA 3' end-specific exonuclease; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; protei; Protein 3'hExo; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1

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          Gene Aliases: 3'EXO; 3'HEXO; 3110010F15Rik; eri-1; ERI1; HEXO; RGD1308378; THEX1

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          UniProt ID: (Human) Q8IV48, (Rat) Q5FVR4, (Mouse) Q9CQ63

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          Entrez Gene ID: (Human) 90459, (Rat) 361159, (Mouse) 67276

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          Molecular Function: exoribonuclease

          Function(s)
          exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) gene silencing by RNA rRNA 3'-end processing histone mRNA catabolic process DNA catabolic process, exonucleolytic rRNA processing nucleic acid phosphodiester bond hydrolysis
          Process(es)
          3'-5' exonuclease activity rRNA binding ribosome binding metal ion binding histone pre-mRNA stem-loop binding 3'-5'-exoribonuclease activity nucleic acid binding RNA binding nuclease activity exonuclease activity hydrolase activity phosphoric ester hydrolase activity T/G mismatch-specific endonuclease activity retroviral 3' processing activity
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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