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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (a.a. 339-353) corresponding to a C-terminal segment of rat ERK1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 4 publications below|
Extracellular signal-regulated kinase 2 (Erk2) is also known as mitogen activated protein kinase 2, microtubule-associated protein-2 kinase MAP kinase 2, p42-MAPK or EGF receptor T669 (ERT1). Mek2 activates Erk2 by phosphorylation of neighbouring threonine-183 and tyrosine-185 residues. Erk2, a serine-threonine kinase phosphorylates microtubule associated protein-2 and myelin basic protein. This kinase is an important proximal componant of the MAP kinase pathway involved in transmitting the signals from growth factors, neurotransmitters and hormones at the cell surface to the transcriptional events in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GPR30 activation is neither necessary nor sufficient for acute neuroprotection by 17β-estradiol after an ischemic injury in organotypic hippocampal slice cultures.
61-7400 was used in western blot to examine the role of GPR30 in 7β-estradiol-mediated neuroprotection after an ischemic injury in an organotypic hippocampal slice culture model.
|Lamprecht MR,Morrison B||Brain research (1563:131)||2014|
CCL2-ethanol interactions and hippocampal synaptic protein expression in a transgenic mouse model.
61-7400 was used in western blot to study the effect of ethanol exposure on CCL2 secretion and hippocampal synaptic protein expression
|Gruol DL,Vo K,Bray JG,Roberts AJ||Frontiers in integrative neuroscience (8:null)||2014|
Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6.
61-7400 was used in western blot to study how elevated levels of IL-6 affect neurons.
|Gruol DL,Puro A,Hao C,Blakely P,Janneke E,Vo K||Journal of neuroimmunology (239:28)||2011|
Conditional, tissue-specific expression of Q205L Galphai2 in vivo mimics insulin activation of c-Jun N-terminal kinase and p38 kinase.
61-7400 was used in western blot to use transgenic mice to study the effect of tissue-specific expression of the constitutively active mutant form (Q205L) of Galphai2.
|Guo JH,Wang HY,Malbon CC||The Journal of biological chemistry (273:16487)||1998|
ERK; ERK-2; ERK1; ERK2; ERT1; extracellular signal-regulated kinase 1; extracellular signal-regulated kinase 2; extracellular signal-related kinase 1; extracellular-signal-regulated kinase 2; insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase 3; MAP kinase isoform p42; MAP kinase isoform p44; MAPK; MAPK 1; MAPK 2; MAPK 3; MAPK2; microtubule-associated protein 2 kinase; Mitogen activated protein kinase; Mitogen activated protein kinase 1; Mitogen activated protein kinase 2; mitogen-activated 3; mitogen-activated protein kinase 1; mitogen-activated protein kinase 2; mitogen-activated protein kinase 3; p41; p41mapk; p42 MAP Kinase; p42-MAPK; P42MAPK; p44 MAP Kinase; pp42/MAP kinase; PRKM1; PRKM2; protein tyrosine kinase ERK2
9030612K14Rik; AA407128; AU018647; C78273; ERK; ERK-1; ERK-2; ERK1; ERK2; ERT1; ERT2; Esrk1; HS44KDAP; HUMKER1A; Mapk; MAPK1; MAPK2; MAPK3; MNK1; Mtap2k; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; p44; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM1; PRKM2; PRKM3