This antibody is predicted to react with bovine, mouse and rat based on sequence homology.
MEK5 and ERK5, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
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Protein Aliases: Big MAP kinase 1; BMK-1; BMK1 kinase; ERK-5; Extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5; MAP kinase 7; MAPK 7; Mitogen-activated protein kinase 7
Gene Aliases: BMK1; ERK4; ERK5; MAPK7; PRKM7
UniProt ID: (Human) Q13164
Entrez Gene ID: (Human) 5598