Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9; C10orf69; Endoplasmic reticulum lipid raft-associated protein 1; Erlin-1; KE04; KEO4; member 1; Protein KE04; SPFH domain family; SPFH domain family, member 1; SPFH domain-containing protein 1; SPFH1; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
Gene Aliases: C10orf69; Erlin-1; ERLIN1; KE04; KEO4; SPFH1; SPG62
UniProt ID: (Human) O75477
Entrez Gene ID: (Human) 10613