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This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: endoplasmic reticulum lumenal protein ERp28; endoplasmic reticulum protein ERp29; Endoplasmic reticulum resident protein 28; Endoplasmic reticulum resident protein 29; Endoplasmic reticulum resident protein 31; endoplasmic retuclum protein 29; epididymis secretory protein Li 107; ERp28; ERp29; ERp31; protein disulfide isomerase family A, member 9
Gene Aliases: 1200015M03Rik; 2810446M09Rik; AW209030; C12orf8; ERP28; ERP29; ERp31; HEL-S-107; PDI-DB; PDIA9
Molecular Function: membrane traffic protein