Description: EndoGlyx-1 is a pan-endothelial human cell surface glycoprotein complex composed of four different disulfide-bonded protein species with an apparent molecular mass of approximately 500 kDa. BMS169 specifically reacts the glycoprotein EndoGlyx-1 that is expressed on endothelial cells of human normal and tumor blood vessel, but not on cells of mesenchymal, neuroectodermal and epithelial derivation.
Applications Tested: Flow Cytometry, Immunohistochemistry, Immunoprecipitation.
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; EMILIN-3; EMILIN-like protein EndoGlyx-1; EndoGlyx-1 p125/p140 subunit; Multimerin-2
Gene Aliases: EMILIN-3; EMILIN3; ENDOGLYX-1; MMRN2
UniProt ID: (Human) Q9H8L6
Entrez Gene ID: (Human) 79812