Enterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), for which there are currently no therapeutics. EV71 virions have icosahedral symmetry and a diameter of approximately 30 nm, comprising 60 copies of the four protein subunits VP1 to VP4. Each of subunits VP1 to VP3 adopts a beta-barrel configuration common to many viruses. EV-A71 2B protein also induced cell apoptosis by modulating Bax protein activation.
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Protein Aliases: Enterovirus